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Protein Folding: Adding a Nucleus to Guide Helix Docking Reduces Landscape Roughness

The elongated three-helix‐bundle spectrin domains R16 and R17 fold and unfold unusually slowly over a rough energy landscape, in contrast to the homologue R15, which folds fast over a much smoother, more typical landscape. R15 folds via a nucleation–condensation mechanism that guides the docking of...

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Detalhes bibliográficos
Main Authors: Wensley, Beth G., Kwa, Lee Gyan, Shammas, Sarah L., Rogers, Joseph M., Clarke, Jane
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469821/
https://ncbi.nlm.nih.gov/pubmed/22917971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.08.003
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