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Novel Aromatase Inhibitors by Structure-Guided Design
[Image: see text] Human cytochrome P450 aromatase catalyzes with high specificity the synthesis of estrogens from androgens. Aromatase inhibitors (AIs) such as exemestane, 6-methylideneandrosta-1,4-diene-3,17-dione, are preeminent drugs for the treatment of estrogen-dependent breast cancer. The crys...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3469775/ https://ncbi.nlm.nih.gov/pubmed/22951074 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300930n |
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