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Mechanism of Inhibition of Estrogen Biosynthesis by Azole Fungicides
Biosynthesis of estrogens from androgens is catalyzed by cytochrome P450 aromatase. Aromatase inhibition by the triazole compounds letrozole (LTZ) and anastrozole is a prevalent therapy for estrogen-dependent postmenopausal breast cancer. Azoles are widely used as agricultural fungicides and antimyc...
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| Publicado no: | Endocrinology |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Endocrine Society
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4239419/ https://ncbi.nlm.nih.gov/pubmed/25243857 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1561 |
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