Clearance of p16(Ink4a)-positive senescent cells delays ageing-associated disorders

Advanced age is the main risk factor for most chronic diseases and functional deficits in humans, but the fundamental mechanisms that drive ageing remain largely unknown, impeding the development of interventions that might delay or prevent age-related disorders and maximize healthy lifespan. Cellul...

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Bibliographic Details
Main Authors: Baker, Darren J., Wijshake, Tobias, Tchkonia, Tamar, LeBrasseur, Nathan K., Childs, Bennett G., van de Sluis, Bart, Kirkland, James L., van Deursen, Jan M.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3468323/
https://ncbi.nlm.nih.gov/pubmed/22048312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10600
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