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Senescent intimal foam cells are deleterious at all stages of atherosclerosis

Advanced atherosclerotic lesions contain senescent cells, but the role of these cells in atherogenesis remains unclear. Using transgenic and pharmacological approaches to eliminate senescent cells in atherosclerosis-prone low-density lipoprotein receptor–deficient (Ldlr(−/−)) mice, we show that thes...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Science
Prif Awduron: Childs, Bennett G., Baker, Darren J., Wijshake, Tobias, Conover, Cheryl A., Campisi, Judith, van Deursen, Jan M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5112585/
https://ncbi.nlm.nih.gov/pubmed/27789842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf6659
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