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Senescent intimal foam cells are deleterious at all stages of atherosclerosis
Advanced atherosclerotic lesions contain senescent cells, but the role of these cells in atherogenesis remains unclear. Using transgenic and pharmacological approaches to eliminate senescent cells in atherosclerosis-prone low-density lipoprotein receptor–deficient (Ldlr(−/−)) mice, we show that thes...
Shranjeno v:
| izdano v: | Science |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5112585/ https://ncbi.nlm.nih.gov/pubmed/27789842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf6659 |
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