Foxp3 Expression is Required for the Induction of Therapeutic Tissue Tolerance()

CD4(+)Foxp3(+) Treg are essential for immune homeostasis and maintenance of self-tolerance. They are produced in the thymus and also generated de novo in the periphery in a TGFβ dependent manner. Foxp3(+) Treg are also required to achieve tolerance to transplanted tissues when induced by co receptor...

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Hauptverfasser: Regateiro, Frederico S., Chen, Ye, Kendal, Adrian R., Hilbrands, Robert, Adams, Elizabeth, Cobbold, Stephen P., Ma, Jianbo, Andersen, Kristian G., Betz, Alexander G., Zhang, Mindy, Madhiwalla, Shruti, Roberts, Bruce, Waldmann, Herman, Nolan, Kathleen F., Howie, Duncan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3467196/
https://ncbi.nlm.nih.gov/pubmed/22988034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200449
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