Induced Foxp3(+) T Cells Colonizing Tolerated Allografts Exhibit the Hypomethylation Pattern Typical of Mature Regulatory T Cells

Regulatory T cells expressing the transcription factor Foxp3 require acquisition of a specific hypomethylation pattern to ensure optimal functional commitment, limited lineage plasticity, and long-term maintenance of tolerance. A better understanding of the molecular mechanisms involved in the gener...

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發表在:Front Immunol
Main Authors: Hilbrands, Robert, Chen, Ye, Kendal, Adrian R., Adams, Elizabeth, Cobbold, Stephen P., Waldmann, Herman, Howie, Duncan
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2016
主題:
Immunology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4827454/
https://ncbi.nlm.nih.gov/pubmed/27148253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00124
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