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Foxp3 drives oxidative phosphorylation and protection from lipotoxicity

Tregs can adopt a catabolic metabolic program with increased capacity for fatty acid oxidation–fueled oxidative phosphorylation (OXPHOS). It is unclear why this form of metabolism is favored in Tregs and, more specifically, whether this program represents an adaptation to the environment and develop...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Howie, Duncan, Cobbold, Stephen Paul, Adams, Elizabeth, Ten Bokum, Annemieke, Necula, Andra Stefania, Zhang, Wei, Huang, Honglei, Roberts, David J., Thomas, Benjamin, Hester, Svenja S., Vaux, David J., Betz, Alexander G., Waldmann, Herman
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5291728/
https://ncbi.nlm.nih.gov/pubmed/28194435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.89160
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