Spi-1/PU.1 activates transcription through clustered DNA occupancy in erythroleukemia

Acute leukemias are characterized by deregulation of transcriptional networks that control the lineage specificity of gene expression. The aberrant overexpression of the Spi-1/PU.1 transcription factor leads to erythroleukemia. To determine how Spi-1 mechanistically influences the transcriptional pr...

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Main Authors: Ridinger-Saison, Maya, Boeva, Valentina, Rimmelé, Pauline, Kulakovskiy, Ivan, Gallais, Isabelle, Levavasseur, Benjamin, Paccard, Caroline, Legoix-Né, Patricia, Morlé, François, Nicolas, Alain, Hupé, Philippe, Barillot, Emmanuel, Moreau-Gachelin, Françoise, Guillouf, Christel
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2012
Fag:
Gene Regulation, Chromatin and Epigenetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3467057/
https://ncbi.nlm.nih.gov/pubmed/22790984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks659
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