Epigenetic silencing of Bim transcription by Spi-1/PU.1 promotes apoptosis resistance in leukaemia

Deregulation of transcriptional networks contributes to haematopoietic malignancies. The transcription factor Spi-1/PU.1 is a master regulator of haematopoiesis and its alteration leads to leukaemia. Spi-1 overexpression inhibits differentiation and promotes resistance to apoptosis in erythroleukaem...

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Autors principals: Ridinger-Saison, M, Evanno, E, Gallais, I, Rimmelé, P, Selimoglu-Buet, D, Sapharikas, E, Moreau-Gachelin, F, Guillouf, C
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
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Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3741512/
https://ncbi.nlm.nih.gov/pubmed/23852375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.88
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