Spi-1/PU.1 transgenic mice develop multistep erythroleukemias.

Insertional mutagenesis of the spi-1 gene is associated with the emergence of malignant proerythroblasts during Friend virus-induced acute erythroleukemia. To determine the role of spi-1/PU.1 in the genesis of leukemia, we generated spi-1 transgenic mice. In one founder line the transgene was overex...

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Autori principali: Moreau-Gachelin, F, Wendling, F, Molina, T, Denis, N, Titeux, M, Grimber, G, Briand, P, Vainchenker, W, Tavitian, A
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1996
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC231234/
https://ncbi.nlm.nih.gov/pubmed/8628313
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