FUS-NLS/Transportin 1 Complex Structure Provides Insights into the Nuclear Targeting Mechanism of FUS and the Implications in ALS

The C-terminal nuclear localization sequence of FUsed in Sarcoma (FUS-NLS) is critical for its nuclear import mediated by transportin (Trn1). Familial amyotrophic lateral sclerosis (ALS) related mutations are clustered in FUS-NLS. We report here the structural, biochemical and cell biological charac...

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Bibliografiske detaljer
Main Authors: Niu, Chunyan, Zhang, Jiayu, Gao, Feng, Yang, Liuqing, Jia, Minze, Zhu, Haining, Gong, Weimin
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3466232/
https://ncbi.nlm.nih.gov/pubmed/23056579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047056
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