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Subcellular localization and RNAs determine FUS architecture in different cellular compartments

Mutations in Fused in sarcoma (FUS) gene cause a subset of familial amyotrophic lateral sclerosis (ALS), a fatal motor neuron degenerative disease. Wild-type FUS is largely localized in the nucleus, but mutant FUS accumulates in the cytoplasm and forms inclusions. It is unclear whether FUS depletion...

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Vydáno v:Hum Mol Genet
Hlavní autoři: Yang, Liuqing, Zhang, Jiayu, Kamelgarn, Marisa, Niu, Chunyan, Gal, Jozsef, Gong, Weimin, Zhu, Haining
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643640/
https://ncbi.nlm.nih.gov/pubmed/26123490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv239
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