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Subcellular localization and RNAs determine FUS architecture in different cellular compartments
Mutations in Fused in sarcoma (FUS) gene cause a subset of familial amyotrophic lateral sclerosis (ALS), a fatal motor neuron degenerative disease. Wild-type FUS is largely localized in the nucleus, but mutant FUS accumulates in the cytoplasm and forms inclusions. It is unclear whether FUS depletion...
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| Gepubliceerd in: | Hum Mol Genet |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Oxford University Press
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4643640/ https://ncbi.nlm.nih.gov/pubmed/26123490 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv239 |
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