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Nuclear localization sequence of FUS and induction of stress granules by ALS mutants

Mutations in FUS have been reported to cause a subset of familial amyotrophic lateral sclerosis (ALS) cases. Wild-type FUS is mostly localized in the nuclei of neurons, but the ALS mutants are partly mislocalized in the cytoplasm and can form inclusions. Little is known about the regulation of FUS s...

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Bibliographic Details
Main Authors: Gal, Jozsef, Zhang, Jiayu, Kwinter, David M., Zhai, Jianjun, Jia, Hongge, Jia, Jianhang, Zhu, Haining
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997923/
https://ncbi.nlm.nih.gov/pubmed/20674093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2010.06.010
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