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Nuclear localization sequence of FUS and induction of stress granules by ALS mutants

Mutations in FUS have been reported to cause a subset of familial amyotrophic lateral sclerosis (ALS) cases. Wild-type FUS is mostly localized in the nuclei of neurons, but the ALS mutants are partly mislocalized in the cytoplasm and can form inclusions. Little is known about the regulation of FUS s...

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Bibliografiske detaljer
Main Authors: Gal, Jozsef, Zhang, Jiayu, Kwinter, David M., Zhai, Jianjun, Jia, Hongge, Jia, Jianhang, Zhu, Haining
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997923/
https://ncbi.nlm.nih.gov/pubmed/20674093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2010.06.010
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