Nuclear localization sequence of FUS and induction of stress granules by ALS mutants

Mutations in FUS have been reported to cause a subset of familial amyotrophic lateral sclerosis (ALS) cases. Wild-type FUS is mostly localized in the nuclei of neurons, but the ALS mutants are partly mislocalized in the cytoplasm and can form inclusions. Little is known about the regulation of FUS s...

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Библиографические подробности
Главные авторы: Gal, Jozsef, Zhang, Jiayu, Kwinter, David M., Zhai, Jianjun, Jia, Hongge, Jia, Jianhang, Zhu, Haining
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997923/
https://ncbi.nlm.nih.gov/pubmed/20674093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2010.06.010
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