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The Structural Basis of DKK-Mediated Inhibition of Wnt/LRP Signaling
Low-density lipoprotein receptor–related proteins 5 and 6 (LRP5/6) mediate canonical Wnt–β-catenin signaling by forming a complex with the co-receptor Frizzled, which binds to Wnt proteins. Dickkopf (DKK)–related proteins inhibit the Wnt signaling pathway by directly binding to the ectodomains of LR...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3465688/ https://ncbi.nlm.nih.gov/pubmed/22589387 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2003028 |
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