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The Structural Basis of DKK-Mediated Inhibition of Wnt/LRP Signaling

Low-density lipoprotein receptor–related proteins 5 and 6 (LRP5/6) mediate canonical Wnt–β-catenin signaling by forming a complex with the co-receptor Frizzled, which binds to Wnt proteins. Dickkopf (DKK)–related proteins inhibit the Wnt signaling pathway by directly binding to the ectodomains of LR...

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Sonraí Bibleagrafaíochta
Main Authors: Bao, Ju, Zheng, Jie J., Wu, Dianqing
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465688/
https://ncbi.nlm.nih.gov/pubmed/22589387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2003028
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