Structural basis of the recognition of the Dishevelled DEP domain in the Wnt signaling pathway

The DEP domain of Dishevelled (Dvl) proteins transduces signals to effector proteins downstream of Dvl in the Wnt pathway. Here we report that DEP-containing mutants inhibit Wnt-induced, but not Dvl-induced, activation of the transcription factor Lef-1. This inhibitory effect is weakened by a K434M...

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Detalhes bibliográficos
Publicado no:Nat Struct Biol
Main Authors: Wong, Hing C., Mao, Junhao, Nguyen, Jason T., Srinivas, Shamala, Zhang, Weixing, Liu, Bo, Li, Lin, Wu, Dianqing, Zheng, Jie
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381838/
https://ncbi.nlm.nih.gov/pubmed/11101902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/82047
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