Structural basis of the recognition of the Dishevelled DEP domain in the Wnt signaling pathway

The DEP domain of Dishevelled (Dvl) proteins transduces signals to effector proteins downstream of Dvl in the Wnt pathway. Here we report that DEP-containing mutants inhibit Wnt-induced, but not Dvl-induced, activation of the transcription factor Lef-1. This inhibitory effect is weakened by a K434M...

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Bibliografiska uppgifter
I publikationen:Nat Struct Biol
Huvudupphovsmän: Wong, Hing C., Mao, Junhao, Nguyen, Jason T., Srinivas, Shamala, Zhang, Weixing, Liu, Bo, Li, Lin, Wu, Dianqing, Zheng, Jie
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2000
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381838/
https://ncbi.nlm.nih.gov/pubmed/11101902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/82047
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