Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled

Wnt binding to members of the seven-span transmembrane Frizzled (Fz) receptor family controls essential cell fate decisions and tissue polarity during development and in adulthood. The Fz-mediated membrane recruitment of the cytoplasmic effector Dishevelled (Dvl) is a critical step in Wnt/β-catenin...

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Detalhes bibliográficos
Main Authors: Tauriello, Daniele V. F., Jordens, Ingrid, Kirchner, Katharina, Slootstra, Jerry W., Kruitwagen, Tom, Bouwman, Britta A. M., Noutsou, Maria, Rüdiger, Stefan G. D., Schwamborn, Klaus, Schambony, Alexandra, Maurice, Madelon M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325702/
https://ncbi.nlm.nih.gov/pubmed/22411803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114802109
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