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Structural Insight into the Mechanisms of Wnt Signaling Antagonism by Dkk
Dickkopf (Dkk) proteins are antagonists of the canonical Wnt signaling pathway and are crucial for embryonic cell fate and bone formation. Wnt antagonism of Dkk requires the binding of the C-terminal cysteine-rich domain of Dkk to the Wnt coreceptor, LRP5/6. However, the structural basis of the inte...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2517007/ https://ncbi.nlm.nih.gov/pubmed/18524778 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802375200 |
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