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Selection of antibodies that regulate phenotype from intracellular combinatorial antibody libraries

A method is presented that uses combinatorial antibody libraries to endow cells with new binding energy landscapes for the purpose of regulating their phenotypes. Antibodies that are expressed in cells infected with a lentiviral combinatorial antibody library are selected directly for function rathe...

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Autori principali: Zhang, Hongkai, Wilson, Ian A., Lerner, Richard A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465454/
https://ncbi.nlm.nih.gov/pubmed/23019357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1214275109
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