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Selection of antibodies that regulate phenotype from intracellular combinatorial antibody libraries

A method is presented that uses combinatorial antibody libraries to endow cells with new binding energy landscapes for the purpose of regulating their phenotypes. Antibodies that are expressed in cells infected with a lentiviral combinatorial antibody library are selected directly for function rathe...

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Bibliographic Details
Main Authors: Zhang, Hongkai, Wilson, Ian A., Lerner, Richard A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465454/
https://ncbi.nlm.nih.gov/pubmed/23019357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1214275109
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