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Libraries against libraries for combinatorial selection of replicating antigen–antibody pairs

Antibodies are among the most highly selective tight-binding ligands for proteins. Because the human genome project has deciphered the proteome, there is an opportunity to use combinatorial antibody libraries to select high-affinity antibodies to every protein encoded by the genome. However, this is...

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Bibliographic Details
Main Authors: Bowley, Diana R., Jones, Teresa M., Burton, Dennis R., Lerner, Richard A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2621251/
https://ncbi.nlm.nih.gov/pubmed/19139405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812291106
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