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Phenotype-information-phenotype cycle for deconvolution of combinatorial antibody libraries selected against complex systems

Use of large combinatorial antibody libraries and next-generation sequencing of nucleic acids are two of the most powerful methods in modern molecular biology. The libraries are screened using the principles of evolutionary selection, albeit in real time, to enrich for members with a particular phen...

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Detalhes bibliográficos
Main Authors: Zhang, Hongkai, Torkamani, Ali, Jones, Teresa M., Ruiz, Diana I., Pons, Jaume, Lerner, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158238/
https://ncbi.nlm.nih.gov/pubmed/21825149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111218108
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