BCAR4 induces antioestrogen resistance but sensitises breast cancer to lapatinib

BACKGROUND: High BCAR4 and ERBB2 mRNA levels in primary breast cancer associate with tamoxifen resistance and poor patient outcome. We determined whether BCAR4 expression sensitises breast cancer cells to lapatinib, and identifies a subgroup of patients who possibly may benefit from ERBB2-targeted t...

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Detaylı Bibliyografya
Asıl Yazarlar: Godinho, M F E, Wulfkuhle, J D, Look, M P, Sieuwerts, A M, Sleijfer, S, Foekens, J A, Petricoin, E F, Dorssers, L C J, van Agthoven, T
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2012
Konular:
Clinical Study
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464772/
https://ncbi.nlm.nih.gov/pubmed/22892392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.351
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