Breast cancer oestrogen independence mediated by BCAR1 or BCAR3 genes is transmitted through mechanisms distinct from the oestrogen receptor signalling pathway or the epidermal growth factor receptor signalling pathway

INTRODUCTION: Tamoxifen is effective for endocrine treatment of oestrogen receptor-positive breast cancers but ultimately fails due to the development of resistance. A functional screen in human breast cancer cells identified two BCAR genes causing oestrogen-independent proliferation. The BCAR1 and...

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Autori principali: Dorssers, Lambert CJ, van Agthoven, Ton, Brinkman, Arend, Veldscholte, Jos, Smid, Marcel, Dechering, Koen J
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2005
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1064102/
https://ncbi.nlm.nih.gov/pubmed/15642172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr954
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