BCAR4 induces antioestrogen resistance but sensitises breast cancer to lapatinib

BACKGROUND: High BCAR4 and ERBB2 mRNA levels in primary breast cancer associate with tamoxifen resistance and poor patient outcome. We determined whether BCAR4 expression sensitises breast cancer cells to lapatinib, and identifies a subgroup of patients who possibly may benefit from ERBB2-targeted t...

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Hlavní autoři: Godinho, M F E, Wulfkuhle, J D, Look, M P, Sieuwerts, A M, Sleijfer, S, Foekens, J A, Petricoin, E F, Dorssers, L C J, van Agthoven, T
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2012
Témata:
Clinical Study
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464772/
https://ncbi.nlm.nih.gov/pubmed/22892392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.351
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