BCAR4 induces antioestrogen resistance but sensitises breast cancer to lapatinib

BACKGROUND: High BCAR4 and ERBB2 mRNA levels in primary breast cancer associate with tamoxifen resistance and poor patient outcome. We determined whether BCAR4 expression sensitises breast cancer cells to lapatinib, and identifies a subgroup of patients who possibly may benefit from ERBB2-targeted t...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Godinho, M F E, Wulfkuhle, J D, Look, M P, Sieuwerts, A M, Sleijfer, S, Foekens, J A, Petricoin, E F, Dorssers, L C J, van Agthoven, T
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2012
Gaiak:
Clinical Study
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464772/
https://ncbi.nlm.nih.gov/pubmed/22892392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.351
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