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Stopping clinical trials early for futility: retrospective analysis of several randomised clinical studies
BACKGROUND: Many clinical trials show no overall benefit. We examined futility analyses applied to trials with different effect sizes. METHODS: Ten randomised cancer trials were retrospectively analysed; target sample size reached in all. The hazard ratio indicated no overall benefit (n=5), or moder...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3464764/ https://ncbi.nlm.nih.gov/pubmed/22878376 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.344 |
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