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Futility stopping in clinical trials, optimality and practical considerations
Stopping for futility is a useful tool in a clinical trial. It is widely used in single-arm trials in oncology and in many two-arm trials. We review three stopping rules for futility. We give recommendations for the optimal timing of futility looks in two- stage trials in terms of the information fr...
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| Publicado en: | J Biopharm Stat |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7954786/ https://ncbi.nlm.nih.gov/pubmed/32926648 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10543406.2020.1818253 |
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