Stopping clinical trials early for futility: retrospective analysis of several randomised clinical studies

BACKGROUND: Many clinical trials show no overall benefit. We examined futility analyses applied to trials with different effect sizes. METHODS: Ten randomised cancer trials were retrospectively analysed; target sample size reached in all. The hazard ratio indicated no overall benefit (n=5), or moder...

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Bibliographic Details
Main Authors: Jitlal, M, Khan, I, Lee, S M, Hackshaw, A
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2012
Subjects:
Clinical Study
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464764/
https://ncbi.nlm.nih.gov/pubmed/22878376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.344
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