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A systematic survey of randomised trials that stopped early for reasons of futility
BACKGROUND: Randomised trial protocols may incorporate interim analyses, with the potential to stop the study for futility if early data show insufficient promise of a treatment benefit. Previously, we have shown that this approach will theoretically lead to mis-estimation of the treatment effect. W...
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| Publicat a: | BMC Med Res Methodol |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6966801/ https://ncbi.nlm.nih.gov/pubmed/31948397 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12874-020-0899-1 |
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