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Conditionally unbiased estimation in phase II/III clinical trials with early stopping for futility
Seamless phase II/III clinical trials combine traditional phases II and III into a single trial that is conducted in two stages, with stage 1 used to answer phase II objectives such as treatment selection and stage 2 used for the confirmatory analysis, which is a phase III objective. Although seamle...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3813981/ https://ncbi.nlm.nih.gov/pubmed/23413228 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.5757 |
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