Insights into the Structural Determinants Required for High Affinity Binding of Chiral Cyclopropane-Containing Ligands to α4β2-Nicotinic Acetylcholine Receptors; An Integrated Approach to Behaviorally Active Nicotinic Ligands

Structure-based drug design can potentially accelerate the development of new therapeutics. In this study, a co-crystal structure of the acetylcholine binding protein (AChBP) from Capitella teleta (Ct) in complex with a cyclopropane-containing, selective α4β2-nicotinic acetylcholine receptor (nAChR)...

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Autori principali: Zhang, Han-Kun, Eaton, J. Brek, Yu, Li-Fang, Nys, Mieke, Mazzolari, Angelica, van Elk, René, Smit, August B., Alexandrov, Vadim, Hanania, Taleen, Sabath, Emily, Fedolak, Allison, Brunner, Daniela, Lukas, Ronald J., Vistoli, Giulio, Ulens, Chris, Kozikowski, Alan P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464052/
https://ncbi.nlm.nih.gov/pubmed/22928944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm3008739
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