Superior Silencing by 2′,4′-BNA(NC)-Based Short Antisense Oligonucleotides Compared to 2′,4′-BNA/LNA-Based Apolipoprotein B Antisense Inhibitors

The duplex stability with target mRNA and the gene silencing potential of a novel bridged nucleic acid analogue are described. The analogue, 2′,4′-BNA(NC) antisense oligonucleotides (AONs) ranging from 10- to 20-nt-long, targeted apolipoprotein B. 2′,4′-BNA(NC) was directly compared to its conventio...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Yamamoto, Tsuyoshi, Yasuhara, Hidenori, Wada, Fumito, Harada-Shiba, Mariko, Imanishi, Takeshi, Obika, Satoshi
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463943/
https://ncbi.nlm.nih.gov/pubmed/23056920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/707323
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars