Superior Silencing by 2′,4′-BNA(NC)-Based Short Antisense Oligonucleotides Compared to 2′,4′-BNA/LNA-Based Apolipoprotein B Antisense Inhibitors

The duplex stability with target mRNA and the gene silencing potential of a novel bridged nucleic acid analogue are described. The analogue, 2′,4′-BNA(NC) antisense oligonucleotides (AONs) ranging from 10- to 20-nt-long, targeted apolipoprotein B. 2′,4′-BNA(NC) was directly compared to its conventio...

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Detalhes bibliográficos
Main Authors: Yamamoto, Tsuyoshi, Yasuhara, Hidenori, Wada, Fumito, Harada-Shiba, Mariko, Imanishi, Takeshi, Obika, Satoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463943/
https://ncbi.nlm.nih.gov/pubmed/23056920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/707323
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