Development of a 2′,4′-BNA/LNA-based siRNA for Dyslipidemia and Assessment of the Effects of Its Chemical Modifications In Vivo

Recent advances in RNA interference (RNAi)-based drug development have partially allowed systemic administration of these agents in vivo with promising therapeutic effects. However, before chemically modified small-interfering RNAs (siRNAs) can be applied clinically, their in vivo effects should be...

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Detalhes bibliográficos
Main Authors: Wada, Shunsuke, Obika, Satoshi, Shibata, Masa-Aki, Yamamoto, Tsuyoshi, Nakatani, Moeka, Yamaoka, Tetsuji, Torigoe, Hidetaka, Harada-Shiba, Mariko
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464879/
https://ncbi.nlm.nih.gov/pubmed/23344237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2012.32
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