Cholesterol-lowering Action of BNA-based Antisense Oligonucleotides Targeting PCSK9 in Atherogenic Diet-induced Hypercholesterolemic Mice

Recent findings in molecular biology implicate the involvement of proprotein convertase subtilisin/kexin type 9 (PCSK9) in low-density lipoprotein receptor (LDLR) protein regulation. The cholesterol-lowering potential of anti-PCSK9 antisense oligonucleotides (AONs) modified with bridged nucleic acid...

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Autori principali: Yamamoto, Tsuyoshi, Harada-Shiba, Mariko, Nakatani, Moeka, Wada, Shunsuke, Yasuhara, Hidenori, Narukawa, Keisuke, Sasaki, Kiyomi, Shibata, Masa-Aki, Torigoe, Hidetaka, Yamaoka, Tetsuji, Imanishi, Takeshi, Obika, Satoshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2012
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393380/
https://ncbi.nlm.nih.gov/pubmed/23344002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2012.16
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