Evaluation of Multiple-Turnover Capability of Locked Nucleic Acid Antisense Oligonucleotides in Cell-Free RNase H-Mediated Antisense Reaction and in Mice

The multiple-turnover ability of a series of locked nucleic acid (LNA)-based antisense oligonucleotides (AONs) in the RNase H-mediated scission reaction was estimated using a newly developed cell-free reaction system. We determined the initial reaction rates of AONs under multiple-turnover condition...

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Detalhes bibliográficos
Main Authors: Yamamoto, Tsuyoshi, Fujii, Naoko, Yasuhara, Hidenori, Wada, Shunsuke, Wada, Fumito, Shigesada, Naoya, Harada-Shiba, Mariko, Obika, Satoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2014
Assuntos:
Brief Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106378/
https://ncbi.nlm.nih.gov/pubmed/24758560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2013.0470
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