PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures

NETosis, the process wherein neutrophils release highly decondensed chromatin called neutrophil extracellular traps (NETs), has gained much attention as an alternative means of killing bacteria. In vivo, NETs are induced by bacteria and pro-inflammatory cytokines. We have reported that peptidylargin...

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Bibliografiska uppgifter
Huvudupphovsmän: Leshner, Marc, Wang, Shu, Lewis, Carrie, Zheng, Han, Chen, Xiangyun Amy, Santy, Lorraine, Wang, Yanming
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2012
Ämnen:
Immunology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463874/
https://ncbi.nlm.nih.gov/pubmed/23060885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2012.00307
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