Human Liver Methionine Cycle: MAT1A and GNMT Gene Resequencing, Functional Genomics, and Hepatic Genotype-Phenotype Correlation

The “methionine cycle” plays a critical role in the regulation of concentrations of (S)-adenosylmethionine (AdoMet), the major biological methyl donor. We set out to study sequence variation in genes encoding the enzyme that synthesizes AdoMet in liver, methionine adenosyltransferase 1A (MAT1A) and...

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主要な著者: Ji, Yuan, Nordgren, Kendra K. S., Chai, Yubo, Hebbring, Scott J., Jenkins, Gregory D., Abo, Ryan P., Peng, Yi, Pelleymounter, Linda L., Moon, Irene, Eckloff, Bruce W., Chai, Xiaoshan, Zhang, Jianping, Fridley, Brooke L., Yee, Vivien C., Wieben, Eric D., Weinshilboum, Richard M.
フォーマット: Artigo
言語:Inglês
出版事項: The American Society for Pharmacology and Experimental Therapeutics 2012
主題:
Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463826/
https://ncbi.nlm.nih.gov/pubmed/22807109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.112.046953
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