The P1/P2 proteins of the human ribosomal stalk are required for ribosome binding and depurination by ricin in human cells

Ricin A chain (RTA) depurinates the sarcin/ricin loop (SRL) of 28S ribosomal RNA and inhibits protein synthesis in mammalian cells. In yeast, the ribosomal stalk facilitates the interaction of RTA with the ribosome and subsequent depurination. Despite homology between the stalk structures from yeast...

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Huvudupphovsmän: May, Kerrie L., Li, Xiao-Ping, Martínez-Azorín, Francisco, Ballesta, Juan P.G., Grela, Przemysław, Tchórzewski, Marek, Tumer, Nilgun E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463775/
https://ncbi.nlm.nih.gov/pubmed/22909382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2012.08752.x
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