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The impact of non-drug-related toxicities on the estimation of the maximum tolerated dose in phase I trials
The rate of observed dose-limiting toxicities (DLTs) determines the maximum tolerated dose (MTD) in phase I trials. There are cases in which non-drug-related toxicities or other cause toxicities (OCTs) are flagged as DLTs, or vice versa, due to attribution errors. We aim to assess the impact of such...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3463734/ https://ncbi.nlm.nih.gov/pubmed/22825582 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-0726 |
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