Designing and Testing Broadly-Protective Filoviral Vaccines Optimized for Cytotoxic T-Lymphocyte Epitope Coverage

We report the rational design and in vivo testing of mosaic proteins for a polyvalent pan-filoviral vaccine using a computational strategy designed for the Human Immunodeficiency Virus type 1 (HIV-1) but also appropriate for Hepatitis C virus (HCV) and potentially other diverse viruses. Mosaics are...

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Bibliografiske detaljer
Main Authors: Fenimore, Paul W., Muhammad, Majidat A., Fischer, William M., Foley, Brian T., Bakken, Russell R., Thurmond, James R., Yusim, Karina, Yoon, Hyejin, Parker, Michael, Hart, Mary Kate, Dye, John M., Korber, Bette, Kuiken, Carla
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463593/
https://ncbi.nlm.nih.gov/pubmed/23056184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044769
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