Designing and Testing Broadly-Protective Filoviral Vaccines Optimized for Cytotoxic T-Lymphocyte Epitope Coverage

We report the rational design and in vivo testing of mosaic proteins for a polyvalent pan-filoviral vaccine using a computational strategy designed for the Human Immunodeficiency Virus type 1 (HIV-1) but also appropriate for Hepatitis C virus (HCV) and potentially other diverse viruses. Mosaics are...

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Detalhes bibliográficos
Main Authors: Fenimore, Paul W., Muhammad, Majidat A., Fischer, William M., Foley, Brian T., Bakken, Russell R., Thurmond, James R., Yusim, Karina, Yoon, Hyejin, Parker, Michael, Hart, Mary Kate, Dye, John M., Korber, Bette, Kuiken, Carla
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463593/
https://ncbi.nlm.nih.gov/pubmed/23056184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044769
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