Designing and Testing Broadly-Protective Filoviral Vaccines Optimized for Cytotoxic T-Lymphocyte Epitope Coverage

We report the rational design and in vivo testing of mosaic proteins for a polyvalent pan-filoviral vaccine using a computational strategy designed for the Human Immunodeficiency Virus type 1 (HIV-1) but also appropriate for Hepatitis C virus (HCV) and potentially other diverse viruses. Mosaics are...

Full description

Saved in:
Bibliographic Details
Main Authors: Fenimore, Paul W., Muhammad, Majidat A., Fischer, William M., Foley, Brian T., Bakken, Russell R., Thurmond, James R., Yusim, Karina, Yoon, Hyejin, Parker, Michael, Hart, Mary Kate, Dye, John M., Korber, Bette, Kuiken, Carla
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463593/
https://ncbi.nlm.nih.gov/pubmed/23056184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044769
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items