Designing and Testing Broadly-Protective Filoviral Vaccines Optimized for Cytotoxic T-Lymphocyte Epitope Coverage

We report the rational design and in vivo testing of mosaic proteins for a polyvalent pan-filoviral vaccine using a computational strategy designed for the Human Immunodeficiency Virus type 1 (HIV-1) but also appropriate for Hepatitis C virus (HCV) and potentially other diverse viruses. Mosaics are...

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Main Authors: Fenimore, Paul W., Muhammad, Majidat A., Fischer, William M., Foley, Brian T., Bakken, Russell R., Thurmond, James R., Yusim, Karina, Yoon, Hyejin, Parker, Michael, Hart, Mary Kate, Dye, John M., Korber, Bette, Kuiken, Carla
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
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Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463593/
https://ncbi.nlm.nih.gov/pubmed/23056184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044769
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