Deficiency of ATP13A2 Leads to Lysosomal Dysfunction, α-Synuclein Accumulation, and Neurotoxicity

The autophagy-lysosomal pathway plays an important role in the clearance of long-lived proteins and dysfunctional organelles. Lysosomal dysfunction has been implicated in several neurodegenerative disorders including Parkinson's disease and related synucleinopathies that are characterized by ac...

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Hlavní autoři: Usenovic, Marija, Tresse, Emilie, Mazzulli, Joseph R., Taylor, J. Paul, Krainc, Dimitri
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2012
Témata:
Brief Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3462811/
https://ncbi.nlm.nih.gov/pubmed/22442086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5575-11.2012
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