G PROTEIN RECEPTOR KINASE 4 (GRK4) POLYMORPHISMS: BETA-BLOCKER PHARMACOGENETICS AND TREATMENT RELATED OUTCOMES IN HYPERTENSION

G protein-coupled receptor kinases (GRKs) are important regulatory proteins for many G protein-coupled receptors, but little is known about GRK4 pharmacogenetics. We hypothesized three nonsynonymous GRK4 SNPs, R65L (rs2960306), A142V (rs1024323) and A486V (rs1801058) would be associated with blood p...

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Auteurs principaux: Vandell, Alexander G., Lobmeyer, Maximilian T., Gawronski, Brian E., Langaee, Taimour Y., Gong, Yan, Gums, John G., Beitelshees, Amber L., Turner, Stephen T., Chapman, Arlene B., Cooper-DeHoff, Rhonda M., Bailey, Kent R., Boerwinkle, Eric, Pepine, Carl J., Liggett, Stephen B., Johnson, Julie A.
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3462355/
https://ncbi.nlm.nih.gov/pubmed/22949529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.112.198721
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