Polymorphisms in genes coding for GRK2 and GRK5 and response differences in antihypertensive treated patients

OBJECTIVES: The G-protein coupled receptor kinases GRK2 and GRK5 are important regulators of beta-adrenergic signaling. This study characterized single nucleotide polymorphisms in the GRK2 gene (ADRBK1)and determined if these and a GRK5 Gln41Leu polymorphism affect the blood pressure (BP)response to...

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Autors principals: Lobmeyer, Maximilian T., Wang, Liewei, Zineh, Issam, Turner, Stephen T., Gums, John G., Chapman, Arlene B., Cooper-DeHoff, Rhonda M, Beitelshees, Amber L., Bailey, Kent R., Boerwinkle, Eric, Pepine, Carl J, Johnson, Julie A.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028503/
https://ncbi.nlm.nih.gov/pubmed/21127457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e328341e911
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