β(2)-Adrenergic Receptor Gene Affects the Heart Rate Response of β-Blockers: Evidence From 3 Clinical Studies

β-Blockers’ heart rate (HR)-lowering effect is an important determinant of the effectiveness for this class of drugs, yet it is variable among β-blocker–treated patients. To date, genetic studies have revealed several genetic signals associated with HR response to β-blockers. However, these genetic...

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Detalhes bibliográficos
Publicado no:J Clin Pharmacol
Main Authors: Shahin, Mohamed H., El Rouby, Nihal, Conrado, Daniela J., Gonzalez, Daniel, Gong, Yan, Lobmeyer, Maximilian T., Beitelshees, Amber L., Boerwinkle, Eric, Gums, John G., Chapman, Arlene, Turner, Stephen T., Pepine, Carl J., Cooper-DeHoff, Rhonda M., Johnson, Julie A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6773496/
https://ncbi.nlm.nih.gov/pubmed/31090079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.1443
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