β(2)-Adrenergic Receptor Gene Affects the Heart Rate Response of β-Blockers: Evidence From 3 Clinical Studies

β-Blockers’ heart rate (HR)-lowering effect is an important determinant of the effectiveness for this class of drugs, yet it is variable among β-blocker–treated patients. To date, genetic studies have revealed several genetic signals associated with HR response to β-blockers. However, these genetic...

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Publicado en:J Clin Pharmacol
Autores principales: Shahin, Mohamed H., El Rouby, Nihal, Conrado, Daniela J., Gonzalez, Daniel, Gong, Yan, Lobmeyer, Maximilian T., Beitelshees, Amber L., Boerwinkle, Eric, Gums, John G., Chapman, Arlene, Turner, Stephen T., Pepine, Carl J., Cooper-DeHoff, Rhonda M., Johnson, Julie A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6773496/
https://ncbi.nlm.nih.gov/pubmed/31090079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.1443
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